S. Bel

Antibiotics damage the colonic mucus barrier in a microbiota-independent manner

This study shows antibiotics damage the colonic mucus barrier independently of microbiota, leading to bacterial penetration and IBD exacerbation.

Optimal antimicrobial response to a changing microbial background at a mucus interface

The paper develops a minimal model to explain how hosts optimize antimicrobial defense at the intestinal mucus interface by integrating signals from bulk microbiota and segmented filamentous bacteria.

Salmonella manipulates the host to drive pathogenicity via induction of interleukin 1β

This study shows that IL-1β production during Salmonella infection is harmful, reducing neutrophil recruitment and inhibiting Salmonella expansion by altering epithelial cell metabolism and complement system interactions.

Autophagy controls mucus secretion from intestinal goblet cells by alleviating ER stress

This study shows that autophagy regulates mucus secretion in intestinal goblet cells by reducing ER stress, thereby maintaining intestinal homeostasis.

Progesterone supplementation in mice leads to microbiome alterations and weight gain in a sex-specific manner

This study shows progesterone increases weight in female mice but not males, with microbiome changes in females only, suggesting sex-specific microbiota involvement in progesterone effects.