The Sec61/TRAP Translocon Scrambles Lipids
M. Javanainen, S. Karki, D. Tranter, D. Biriukov, V. O. Paavilainen
The paper investigates the lipid scrambling activity of Sec61 and TRAP using molecular dynamics simulations, showing they facilitate lipid flip-flop via a credit card mechanism and are selective for phosphatidylcholine.
bioRxiv · Nov 23, 2023 · PreprintBiophysics