M. Javanainen

A comparison of lipid diffusive dynamics in monolayers and bilayers in the context of interleaflet coupling

This study compares lipid diffusive dynamics in monolayers and bilayers to understand interleaflet coupling mechanisms.

Energetics of the Transmembrane Peptide Sorting by Hydrophobic Mismatch

This study uses molecular dynamics simulations to investigate how hydrophobic mismatch affects the lateral sorting of transmembrane peptides by analyzing free energy profiles and peptide orientation.

Can calmodulin bind to lipids of the cytosolic leaflet of plasma membranes?

The paper investigates whether calmodulin binds to lipids in the cytosolic leaflet of plasma membranes and finds that CaM interacts with PS and PE, with calcium inducing conformational changes and affecting membrane charge and stability.

The Sec61/TRAP Translocon Scrambles Lipids

The paper investigates the lipid scrambling activity of Sec61 and TRAP using molecular dynamics simulations, showing they facilitate lipid flip-flop via a credit card mechanism and are selective for phosphatidylcholine.

Exposure to aldehyde cherry e-liquid flavouring and its vape by-product disrupts pulmonary surfactant biophysical function

This study shows that benzaldehyde and its by-product, benzaldehyde propylene glycol acetal, disrupt pulmonary surfactant biophysical function by interacting with surfactant proteins SP-B and SP-C.

Nanoscale membrane curvature sorts lipid phases and alters lipid diffusion

This study uses single-molecule microscopy and simulations to show that nanoscale membrane curvature induces lipid phase separation and alters lipid diffusion.

Efficient Simulations of Membrane and Solvent Asymmetry With Flat-Bottom Restraints

This paper introduces a method to efficiently simulate asymmetric lipid membranes and solvent environments using flat-bottom restraints, achieving results comparable to a costly double-bilayer setup.

Protein Crowding and Cholesterol Increase Cell Membrane Viscosity in a Temperature Dependent Manner

This study uses molecular dynamics simulations to investigate how protein crowding, cholesterol, lipid composition, and temperature affect membrane viscosity, finding that cholesterol and protein concentration have larger effects than lipid chain properties.

Surfactant Proteins SP-B and SP-C in Pulmonary Surfactant Monolayers: Physical Properties Controlled by Specific Protein-Lipid Interactions

This study uses molecular dynamics simulations and experimental techniques to investigate how surfactant proteins SP-B and SP-C interact with lipid monolayers, revealing their role in modulating surface pressure and phase behavior.

Molecular view of ER membrane remodeling by the Sec61/TRAP translocon

The paper determines the structure of the Sec61/TRAP complex bound to a ribosome using Cryo-EM, revealing how TRAP facilitates ER membrane remodeling and polypeptide translocation.

Signal peptide mimicry primes Sec61 for client-selective inhibition

This study describes KZR-8445, a cyclic depsipeptide that selectively inhibits Sec61-mediated protein biogenesis by mimicking signal peptides, showing efficacy in a rheumatoid arthritis model.