Relative Mutant N501Y SARS-CoV-2 Spike Protein RBD Inhibition of Anti-Spike Protein IgG and ACE-2 Binding to Spike Protein Species
M. E. Klegerman, J. D. Cirillo, D. D. McPherson
The paper investigates the effect of the N501Y mutation in the SARS-CoV-2 spike protein RBD on ACE-2 and antibody binding, finding that the mutation reduces RBD-antibody affinity but not ACE-2 binding.
bioRxiv · Apr 26, 2021 · PreprintBiochemistry