Author

J. D. Cirillo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. B. Benjamin· 1 shared A. E. Barron· 1 shared A. Kay· 1 shared A. M. Mandalakas· 1 shared A. R. DiNardo· 1 shared C. Coarfa· 1 shared C. Herlan· 1 shared D. D. McPherson· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperMicrobiology

A. B. Benjamin

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Peptide-mimetic treatment of Pseudomonas aeruginosa in a mouse model of respiratory infection

M. G. Moule, A. B. Benjamin, M. L. Burger, C. Herlan, M. Lebedev, J. S. Lin, K. J. Koster, N. Wavare, L. G. Adams, S. Bräse, A. E. Barron, J. D. Cirillo

This study demonstrates that the peptide-mimetic TM5 effectively kills Pseudomonas aeruginosa in vitro and reduces bacterial load in a mouse model of infection with low toxicity.

bioRxiv · Oct 30, 2023 · PreprintMicrobiology

Relative Mutant N501Y SARS-CoV-2 Spike Protein RBD Inhibition of Anti-Spike Protein IgG and ACE-2 Binding to Spike Protein Species

M. E. Klegerman, J. D. Cirillo, D. D. McPherson

The paper investigates the effect of the N501Y mutation in the SARS-CoV-2 spike protein RBD on ACE-2 and antibody binding, finding that the mutation reduces RBD-antibody affinity but not ACE-2 binding.

bioRxiv · Apr 26, 2021 · PreprintBiochemistry

Persistent DNA Hyper-methylation Dampens Host Anti-Mycobacterial Immunity

A. R. DiNardo, K. Rajapakshe, T. Nishiguchi, G. Mtetwa, Q. Dlamini, J. Kahari, S. Mahapatra, A. Kay, G. Maphalala, E. Mace, S. L. Grimm, G. Makedonas, J. D. Cirillo, M. G. Netea, R. van Crevel, , A. M. Mandalakas

This study identifies DNA hyper-methylation in immune-related pathways of TB patients, leading to reduced immune responsiveness to mycobacterial antigens.

bioRxiv · Oct 16, 2019 · PreprintImmunology