Neutralizing antibody-independent immunity to SARS-CoV-2 in hamsters and hACE-2 transgenic mice immunized with a RBD/Nucleocapsid fusion protein
J. Castro, M. Fumagalli, N. Hojo-Souza, P. Azevedo, N. Salazar, B. Rattis, S. Ramos, L. Faustino, G. Almeida, L. Oliveira, T. Marcal, M. Augusto, R. D. M. Magalhaes, B. Cassaro, G. Burle, , R. Gazzinelli
This study shows that a RBD/Nucleocapsid fusion protein induces strong T cell responses and protects against SARS-CoV-2 without neutralizing antibodies in hamsters and hACE-2 mice.
bioRxiv · Sep 16, 2021 · PreprintImmunology