M. Fumagalli

Mitochondrial metabolism sustains CD8+ T cellmigration for an efficient infiltration into solid tumors

This study shows mitochondrial metabolism, not glycolysis, is essential for CD8+ T cell migration in 3D tumor environments, and enhancing mitochondrial activity improves CAR T cell infiltration and tumor control.

Neutralizing antibody-independent immunity to SARS-CoV-2 in hamsters and hACE-2 transgenic mice immunized with a RBD/Nucleocapsid fusion protein

This study shows that a RBD/Nucleocapsid fusion protein induces strong T cell responses and protects against SARS-CoV-2 without neutralizing antibodies in hamsters and hACE-2 mice.

Detecting adaptive introgression in human evolution using convolutional neural networks

This paper develops a convolutional neural network to detect adaptive introgression in human genomes using simulated and real data, achieving 95% accuracy on simulated datasets.

Distinguishing between recent balancing selection and incomplete sweep using deep neural networks

This study uses deep neural networks to distinguish between recent balancing selection and incomplete sweep in genomic data, identifying variants potentially linked to disease susceptibility.

Sex-biased gene expression resolves sexual conflict through the evolution of sex-specific genetic architecture

The paper uses transcriptome data from guppies to show that sexual conflict is resolved through male-biased gene expression and sex-specific genetic architecture.

Archaic adaptive introgression in TBX15/WARS2

The paper identifies an archaic adaptive introgression in the TBX15/WARS2 region in Greenlandic Inuit, showing its association with gene expression and DNA methylation changes.