IL-33 regulates age-dependency of long-term immune dysfunction induced by sepsis
D. F. Colon, C. W. Wanderley, W. Turato, V. F. Borges, M. Franchin, F. V. S. Castanheira, D. Nascimento, D. Prado, M. H. de Lima, L. C. Volpon, S. K. Kavaguti, F. Ramalho, A. P. Carlotti, F. Carmona, B. S. Franklin, , F. d. Q. Cunha
This study shows that IL-33 plays an age-dependent role in post-sepsis immunosuppression, with adults showing increased IL-33 and Tregs while infants are resistant to secondary infections.
bioRxiv · Jan 15, 2022 · PreprintImmunology