Author

B. S. Franklin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Assay:proteomics· 3 Organism:mouse· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

I. Hawwari· 3 shared E. Latz· 2 shared L. H. Carvalho· 2 shared L. S. Ribeiro· 2 shared M. L. S. Santos· 2 shared S. Maasewerd· 2 shared A. Demczuk· 1 shared A. P. Carlotti· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersImmunology

I. Hawwari

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Platelet-derived transcription factors license human monocyte 1 inflammation

I. Hawwari, N. Rosero, S. Maasewerd, M. Jentzsch, A. Demczuk, L. S. Ribeiro, L. S. Teichmann, L. Meffert, S. Kallabis, F. Meissner, M. Noval Rivas, M. A. Arditi, D. Bertheloot, B. S. Franklin

This study shows platelets are crucial for human monocyte inflammation, as their absence causes immunoparalysis and their addition restores cytokine responses.

bioRxiv · Aug 10, 2022Immunology

IL-33 regulates age-dependency of long-term immune dysfunction induced by sepsis

D. F. Colon, C. W. Wanderley, W. Turato, V. F. Borges, M. Franchin, F. V. S. Castanheira, D. Nascimento, D. Prado, M. H. de Lima, L. C. Volpon, S. K. Kavaguti, F. Ramalho, A. P. Carlotti, F. Carmona, B. S. Franklin, , F. d. Q. Cunha

This study shows that IL-33 plays an age-dependent role in post-sepsis immunosuppression, with adults showing increased IL-33 and Tregs while infants are resistant to secondary infections.

bioRxiv · Jan 15, 2022 · PreprintImmunology

A distinct fingerprint of inflammatory mediators and miRNAs in Plasmodium vivax severe thrombocytopenia

M. L. S. Santos, R. S. Coimbra, T. N. Sousa, L. F. F. Guimaraes, M. S. Gomes, L. R. Amaral, D. Pereira, C. J. F. Fontes, I. Hawwari, B. S. Franklin, L. H. Carvalho

The paper identifies inflammatory mediators and miRNAs associated with severe thrombocytopenia in Plasmodium vivax infections using proteomics, miRNA quantification, and machine learning.

bioRxiv · Aug 20, 2020 · PreprintMicrobiology

Platelets fuel the inflammasome activation of innate immune cells

V. Rolfes, L. S. Ribeiro, I. Hawwari, L. Buotcher, N. S. Rosero, S. Maasewerd, M. L. S. Santos, S. V. Schmidt, M. Rothe, J. Stunden, L. H. Carvalho, C. J. Fontes, T. Prochnicki, M. Arditi, E. Latz, B. S. Franklin

This study shows platelets enhance inflammasome activation in immune cells, increasing IL-1β production, and identifies a platelet gene signature linked to autoinflammatory diseases.

bioRxiv · Oct 11, 2019Immunology

Charcot-Leyden Crystals activate the NLRP3 inflammasome and cause IL-1β inflammation

J. F. Rodrigues-Alcazar, M. A. Ataide, G. Engels, C. Schmitt-Mabmunyo, N. Garbi, W. Kastenmueller, E. Latz, B. S. Franklin

This study shows that Charcot-Leyden crystals activate the NLRP3 inflammasome, leading to IL-1β release and inflammation in vitro and in vivo.

bioRxiv · Jan 25, 2018Immunology