Gene Deletion Studies Reveal A Critical Role For Prostamide/Prostaglandin F2α Synthase In Prostamide F2α Formation
J. A. Bertrand, D. F. Woodward, J. M. Sherwood, A. Spenlehauer, C. Silvestri, F. Piscitelli, V. Di Marzo, M. Yamazaki, K. Sakimura, K. Watanabe, D. Overby
This study deletes the PM/PGFS gene in mice and finds elevated intraocular pressure, suggesting PM/PGFS regulates prostanoid levels that affect eye pressure.
bioRxiv · Apr 1, 2020 · PreprintPharmacology & Toxicology