Protomer alignment modulates specificity of RNA substrate recognition by Ire1
W. Li, K. Crotty, D. G. Ruiz, M. Voorhies, C. Rivera, A. Sil, D. Mullins, M. Jacobson, J. Peschek, P. Walter
The paper shows that changing two amino acids in S. cerevisiae Ire1 to their S. pombe counterparts makes it promiscuous, revealing that protomer alignment modulates RNA substrate specificity.
eLife · Apr 27, 2021Peer-reviewedBiochemistry