IgA Potentiates NETosis in Response to Viral Infection
H. D. Stacey, D. Golubeva, A. Posca, J. C. Ang, K. E. Novakowski, M. A. Zahoor, C. Kaushic, E. Cairns, D. Bowdish, C. E. Mullarkey, M. S. Miller
This study shows that IgA:virus immune complexes enhance NETosis in neutrophils via FcRI engagement, independent of TLRs, and demonstrate NETs' ability to trap and inactivate viruses.
bioRxiv · Jan 4, 2021Immunology