M. S. Miller

Distinctive retinal peri-arteriolar versus peri-venular amyloid plaque distribution correlates with the cognitive performance

The paper quantifies retinal perivascular amyloid plaque distribution in relation to cognitive performance, finding higher peri-arteriolar amyloid burden and correlations with cognitive decline.

Targeting the MR1-MAIT Cell Axis Improves Vaccine Efficacy and Affords Protection against Viral Pathogens

This study shows that targeting the MR1-MAIT cell axis with 5-OP-RU enhances vaccine efficacy against viral pathogens by expanding and reprogramming MAIT cells.

Comprehensive analysis of the human ESCRT-III-MIT domain interactome reveals new cofactors for cytokinetic abscission

This study maps the human MIT-ESCRT-III interactome, identifies new cofactors for cytokinetic abscission, and reveals their functional roles in abscission and regulation.

Broadly-neutralizing antibodies that bind to the influenza hemagglutinin stalk domain enhance the effectiveness of neuraminidase inhibitors via Fc-mediated effector functions

This study shows stalk-binding antibodies enhance neuraminidase inhibitor effectiveness through Fc-mediated effector functions, suggesting a synergistic effect in influenza treatment.

Single-dose respiratory mucosal delivery of next-generation viral-vectored COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2

This study evaluates a multivalent Ad-vectored vaccine delivered via respiratory mucosal route, showing robust protection against SARS-CoV-2 and variants in mice.

Gut microbiota-based vaccination engages innate immunity to improve blood glucose control in obese mice

This study shows that gut microbiota-based vaccination improves blood glucose control in obese mice by engaging innate immunity, requiring bacterial components and specific immune proteins.

IgA Potentiates NETosis in Response to Viral Infection

This study shows that IgA:virus immune complexes enhance NETosis in neutrophils via FcRI engagement, independent of TLRs, and demonstrate NETs' ability to trap and inactivate viruses.

Potentiation of Long-Acting β2-Agonist and Glucocorticoid Responses in Human Airway Epithelial Cells by Modulation of Intracellular cAMP

This study shows that inhibiting PDE4 or ABCC4 enhances the anti-inflammatory effects of LABA/GCS in human airway epithelial cells exposed to viral stimuli.

Experimental and natural evidence of SARS-CoV-2 infection-induced activation of type I interferon responses

This study shows SARS-CoV-2 infection induces a mild type I IFN response in vitro and in moderate COVID-19 cases, and cannot inhibit exogenous IFN induction.

Cross-sectional evaluation of humoral responses against SARS-CoV-2 Spike

This study evaluates humoral responses against SARS-CoV-2 Spike in 106 infected individuals, finding persistent RBD-specific IgG and declining neutralizing activity over time.

Isolation, sequence, infectivity and replication kinetics of SARS-CoV-2

The paper isolates SARS-CoV-2 from two patients, sequences the virus, and tests its infectivity in human immune cells, finding that PBMCs are not permissive to infection.

Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue

The paper examines gene expression and protein localization of potential SARS-CoV-2 receptors in human airway epithelial cells and lung tissue, finding low ACE2 expression and confirming other candidate receptors.