TDP-43 pathology links innate and adaptive immunity in amyotrophic lateral sclerosis
B. A. Evangelista, J. V. Ragusa, K. Pellegrino, Y. Wu, I. Quiroga-Barber, S. R. Cahalan, O. K. Arooji, J. A. Madren, S. Schroeter, J. Cozzarin, L. Xie, X. Chen, K. K. White, J. A. Ezzell, M. A. Iannone, , T. J. Cohen
This study shows TDP-43 pathology activates immune cells in ALS, linking it to immune dysfunction and suggesting immune monitoring as a diagnostic tool.
bioRxiv · Jan 7, 2024 · PreprintCell Biology