Author

D. Hercules

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

C. D. Okafor· 2 shared E. A. Ortlund· 1 shared e. Ortlund· 1 shared G. Eick· 1 shared J. K. Colucci· 1 shared J. W. Thornton· 1 shared K. Cottrill· 1 shared M. L. Cato· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiochemistry

C. D. Okafor

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Author profile →

2 papers

Recent·Most cited

The nuclear receptor LRH-1 discriminates between ligands using distinct allosteric signaling circuits

S. Mays, D. Hercules, e. Ortlund, C. D. Okafor

This study identifies distinct allosteric signaling circuits used by active and inactive ligands to communicate with the AFS of LRH-1, revealing new therapeutic targets and mechanisms of coregulator signaling.

bioRxiv · Jan 27, 2023Biochemistry

Evolutionary tuning of a key helix drove androgen selectivity

C. D. Okafor, J. K. Colucci, M. L. Cato, S. H. Khan, K. Cottrill, D. Hercules, G. Eick, J. W. Thornton, E. A. Ortlund

The paper investigates how evolutionary changes in helix 10 of androgen receptors drove ligand selectivity by analyzing ancestral proteins and biophysical mechanisms.

bioRxiv · Jul 21, 2021 · PreprintEvolutionary Biology