Author

M. L. Cato

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1

Frequent Co-Authors

E. A. Ortlund· 4 shared A. B. Patel· 2 shared C. D. Okafor· 2 shared D. Melchers· 2 shared E. H. D'Agostino· 2 shared J. L. Cornelison· 2 shared N. T. Jui· 2 shared R. Houtman· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersBiochemistry

E. A. Ortlund

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen tests

F. Frank, M. M. Keen, A. Rao, L. Bassit, X. Liu, H. B. Bowers, A. B. Patel, M. L. Cato, J. A. Sullivan, M. Greenleaf, A. Piantadosi, W. Lam, W. Hudson, E. A. Ortlund

bioRxiv · May 19, 2022Immunology

Evolutionary tuning of a key helix drove androgen selectivity

C. D. Okafor, J. K. Colucci, M. L. Cato, S. H. Khan, K. Cottrill, D. Hercules, G. Eick, J. W. Thornton, E. A. Ortlund

The paper investigates how evolutionary changes in helix 10 of androgen receptors drove ligand selectivity by analyzing ancestral proteins and biophysical mechanisms.

bioRxiv · Jul 21, 2021 · PreprintEvolutionary Biology

Tapping into a phospholipid-LRH-1 axis yields a powerful anti-inflammatory agent with in vivo activity against colitis

S. G. Mays, E. H. D'Agostino, A. R. Flynn, X. Huang, G. Wang, X. Liu, E. J. Millings, C. D. Okafor, A. Patel, M. L. Cato, J. L. Cornelison, D. Melchers, R. Houtman, D. D. Moore, J. W. Calvert, , E. A. Ortlund

The paper develops a phospholipid-mimicking LRH-1 agonist that shows in vivo efficacy in a colitis model by improving binding affinity and transcriptional activity.

bioRxiv · Sep 1, 2020 · PreprintBiochemistry

Development of a new class of liver receptor homolog-1 (LRH-1) agonists by photoredox conjugate addition

J. L. Cornelison, M. L. Cato, A. M. Johnson, E. H. D'Agostino, D. Melchers, A. B. Patel, S. G. Mays, R. Houtman, E. A. Ortlund, N. T. Jui

This study develops a new class of LRH-1 agonists using a photoredox conjugate addition method, enabling bridgehead substitution to enhance ligand activation.

bioRxiv · Mar 16, 2020Biochemistry