Author

D. Ireland

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 5 Animal Behavior & Cognition· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:plant (other)· 6 Assay:behavioral assay· 5 Research Focus:host-pathogen & immune response· 5 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1

Frequent Co-Authors

C. Rabeler· 5 shared E.-M. Collins· 4 shared E.-M. S. Collins· 2 shared S. Zhang· 2 shared V. Bochenek· 2 shared A. Ho· 1 shared A. Soni· 1 shared D. Chaiken· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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5 shared papersPharmacology & Toxicology

C. Rabeler

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Author profile →

6 papers

Recent·Most cited

Adult and regenerating planarians respond differentially to chronic drug exposure

K. Bayingana, D. Ireland, E. Rosenthal, C. Rabeler, E.-M. Collins

This study tests the effects of ten common drugs and stimulants on adult and regenerating planarians, finding differential impacts on morphology and behavior.

bioRxiv · Aug 2, 2022Pharmacology & Toxicology

Differences in neurotoxic outcomes of organophosphorus pesticides revealed via multi-dimensional screening in adult and regenerating planarians

D. Ireland, S. Zhang, V. Bochenek, J.-H. Hsieh, C. Rabeler, Z. Meyer, E.-M. Collins

This study screens seven organophosphorus pesticides across concentrations in planarians to differentiate neurotoxicity from developmental neurotoxicity, finding distinct toxicological profiles and developmental-specific mechanisms.

bioRxiv · Jun 20, 2022 · PreprintPharmacology & Toxicology

Bioactivation and detoxification of organophosphorus pesticides in freshwater planarians shares similarities with humans

D. Ireland, C. Rabeler, T. Gong, E.-M. Collins

This study shows that freshwater planarians have OP metabolic machinery similar to humans, making them a relevant model for OP toxicity research.

bioRxiv · Jun 20, 2022Pharmacology & Toxicology

Dugesia japonica is the best suited of three planarian species for high-throughput toxicology screening

D. Ireland, V. Bochenek, D. Chaiken, C. Rabeler, S. Onoe, A. Soni, E.-M. S. Collins

This study compares three planarian species for high-throughput toxicology screening, finding that Dugesia japonica is best suited due to better behavioral responses and fewer limitations under HTS conditions.

bioRxiv · Jan 23, 2020Pharmacology & Toxicology

Pharmacological or genetic targeting of Transient Receptor Potential (TRP) channels can disrupt the planarian escape response

Z. Sabry, A. Ho, D. Ireland, C. Rabeler, O. Cochet-Escartin, E.-M. Collins

This study shows that TRP channels mediate planarian escape responses to noxious stimuli, with TRPA1 and TRPV involved in different inducers but converging on a common downstream pathway.

bioRxiv · Sep 3, 2019Animal Behavior & Cognition

Screening for neurotoxic potential of 15 flame retardants using freshwater planarians

S. Zhang, D. Ireland, N. S. Sipes, M. Behl, E.-M. S. Collins

This study screens 15 flame retardants using freshwater planarians to assess neurotoxicity, finding 11 compounds caused adverse effects in both adults and developing organisms, with OPFRs showing comparable toxicity to phased-out BFRs.

bioRxiv · Feb 1, 2019Pharmacology & Toxicology