Does human P-glycoprotein efflux involve transmembrane alpha helix breakage?
C. A. Bonito, M. J. U. Ferreira, R. Ferreira, D. J. dos Santos
The paper challenges the validity of an occluded conformation of human P-glycoprotein, suggesting it may be an artifact from nanodisc size limitations.
bioRxiv · Jul 5, 2019 · PreprintBiophysics