Author

C. A. Bonito

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

D. J. dos Santos· 1 shared D. J. V. A. dos Santos· 1 shared J.-P. Gillet· 1 shared M. J. U. Ferreira· 1 shared M. N. D. S. Cordeiro· 1 shared M.-J. U. Ferreira· 1 shared R. Ferreira· 1 shared R. J. Ferreira· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 13 mutual co-author links

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1 shared paperBiophysics

D. J. dos Santos

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2 papers

Recent·Most cited

Long-range communication between transmembrane- and nucleotide-binding domains does not depend on drug binding to mutant P-glycoprotein

C. A. Bonito, R. J. Ferreira, M.-J. U. Ferreira, J.-P. Gillet, M. N. D. S. Cordeiro, D. J. V. A. dos Santos

This study evaluates how four P-gp mutations affect drug-binding and efflux mechanisms, finding that changes in drug efflux are more related to drug specificity than signal transmission.

bioRxiv · Jun 30, 2022Biophysics

Does human P-glycoprotein efflux involve transmembrane alpha helix breakage?

C. A. Bonito, M. J. U. Ferreira, R. Ferreira, D. J. dos Santos

The paper challenges the validity of an occluded conformation of human P-glycoprotein, suggesting it may be an artifact from nanodisc size limitations.

bioRxiv · Jul 5, 2019 · PreprintBiophysics