R. Ferreira

Hiding in Plain Sight: Thymic CD8+FOXP3+Tregs sequester CD25 and are enriched in human tissues

The paper identifies CD8+FOXP3+ Tregs enriched in human tissues, expressing intracellular CD25 and tissue residency markers, and demonstrates their therapeutic potential and association with disease states.

Multilevel Plasticity and Altered Glycosylation Drive Aggressiveness in Hypoxic and Glucose-Deprived Bladder Cancer Cells

This study identifies hypoxia and glucose deprivation as drivers of aggressiveness in bladder cancer through metabolic adaptation and altered glycosylation.

Biosensor-Assisted Laboratory Evolution of Malonyl-CoA production in Saccharomyces cerevisiae

This study develops a CRISPR-dCas9 platform to enhance malonyl-CoA production in yeast through laboratory evolution.

Screening in serum-derived medium reveals differential response to compounds targeting metabolism

The paper screens compounds targeting metabolism in serum-derived medium to identify differential responses in cancer cells, aiming to improve drug response prediction.

Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress

The paper shows that nucleotide depletion and DNA replication stress drive cell fate transitions in hematopoietic systems by activating lineage-specific maturation genes.

Structure-based identification of naphthoquinones and derivatives as novel inhibitors of main protease Mpro and papain-like protease PLpro of SARS-CoV-2

This study identifies naphthoquinone derivatives as inhibitors of SARS-CoV-2 proteases Mpro and PLpro through virtual screening and biochemical assays.

Metabolomics, Transcriptomics and Functional Glycomics Reveals Bladder Cancer Cells Plasticity and Enhanced Aggressiveness Facing Hypoxia and Glucose Deprivation

This study shows that bladder cancer cells become more aggressive under hypoxia and glucose deprivation through metabolic and glycosylation changes.

Nuclear stabilisation of p53 requires a functional nucleolar surveillance pathway

This study identifies the nucleolar surveillance pathway (NSP) as a central regulator of p53 stability, showing its role in integrating various cellular stresses and its potential as a therapeutic target in cancer.

Dissecting cell type-specific metabolism in pancreatic ductal adenocarcinoma

The paper uses isotope tracing to compare metabolism between cancer cells and fibroblasts in pancreatic tumors, identifying key metabolic dependencies in cancer cells.

Mechanistic Elucidation of the Antitumor Properties of a Novel Death Receptor 5 Activator

This study identifies DDAs as compounds that upregulate DR5 in cancer cells, leading to apoptosis and synergy with TRAIL, with selectivity for oncogene-transformed cells.

Does human P-glycoprotein efflux involve transmembrane alpha helix breakage?

The paper challenges the validity of an occluded conformation of human P-glycoprotein, suggesting it may be an artifact from nanodisc size limitations.

The plasma biomarker soluble SIGLEC-1 is associated with the type I interferon transcriptional signature, ethnic background and renal disease in systemic lupus erythematosus

This paper develops an immunoassay for sSIGLEC-1, showing its association with IFN signature, ancestry, and renal disease in SLE.