BRCA1 Mediated Homologous Recombination and S Phase DNA Repair Pathways Restrict LINE-1 Retrotransposition in Human Cells
X. Sun, P. Mita, D. J. Kahler, D. Li, A. Wudzinska, C. Yun, J. S. Bader, D. Fenyo, J. D. Boeke
This study identifies BRCA1 and other DNA repair factors that suppress LINE-1 retrotransposition in human cells by affecting retrotransposition frequency and ORF2 protein translation.
bioRxiv · Jul 13, 2019Cell Biology