Author

P. Mita

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Wudzinska· 2 shared C. Yun· 2 shared D. Fenyo· 2 shared D. Fenyö· 2 shared J. Boeke· 2 shared J. D. Boeke· 2 shared J. LaCava· 2 shared W. McKerrow· 2 shared

Activity by Year

2017-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersCell Biology

A. Wudzinska

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Author profile →

5 papers

Recent·Most cited

LINE-1 ORF1p RIP-seq reveals widespread association with p-body enriched mRNAs

E. M. Briggs, W. McKerrow, P. Mita, J. D. Boeke, S. K. Logan, D. Fenyö

The paper uses RIP-seq and L1EM analysis to show ORF1p binds non-LINE-1 mRNAs and p-body enriched RNAs in prostate cancer cells, correlating with LINE-1 RNA levels in TCGA tumors.

bioRxiv · Aug 20, 2020Cell Biology

LINE-1 expression in cancer correlates with DNA damage response, copy number variation, and cell cycle progression

W. McKerrow, X. Wang, P. Mita, S. Cao, M. Grivainis, L. Ding, J. LaCava, J. Boeke, D. Fenyö

bioRxiv · Jun 26, 2020 · PreprintCancer Biology

SHP2 Inhibition Abrogates Adaptive Resistance to KRASG12C-Inhibition and Remodels the Tumor Microenvironment of KRAS-Mutant Tumors

C. Fedele, S. Li, K. W. Teng, C. Foster, D. Peng, H. Ran, P. Mita, M. Geer, T. Hattori, A. Koide, Y. Wang, K. H. Tang, J. Leinwand, W. Wang, B. Diskin, , B. G. Neel

This study shows that combining SHP2 inhibitors with KRASG12C inhibitors enhances efficacy in PDAC and NSCLC by overcoming resistance and remodeling the tumor microenvironment.

bioRxiv · May 30, 2020Cancer Biology

BRCA1 Mediated Homologous Recombination and S Phase DNA Repair Pathways Restrict LINE-1 Retrotransposition in Human Cells

X. Sun, P. Mita, D. J. Kahler, D. Li, A. Wudzinska, C. Yun, J. S. Bader, D. Fenyo, J. D. Boeke

This study identifies BRCA1 and other DNA repair factors that suppress LINE-1 retrotransposition in human cells by affecting retrotransposition frequency and ORF2 protein translation.

bioRxiv · Jul 13, 2019Cell Biology

LINE-1 and the cell cycle: protein localization and functional dynamics

P. Mita, A. Wudzinska, X. Sun, J. Andrade, S. Nayak, D. Kahler, S. Badri, J. LaCava, B. Ueberheide, C. Yun, D. Fenyo, J. Boeke

This study identifies L1 protein nuclear entry mechanisms and shows a cell cycle bias for L1 retrotransposition peaking in S phase.

bioRxiv · Jun 30, 2017Cell Biology