Author

D. J. Tward

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Assay:imaging· 4 Approach:statistical model· 4 Research Focus:cell type annotation· 3 Approach:deep learning· 3 Research Focus:spatial domain detection· 3 Assay:spatial transcriptomics· 3 Research Focus:benchmarking· 1

Frequent Co-Authors

K. Stouffer· 3 shared M. I. Miller· 3 shared M. Witter· 3 shared C. Chen· 2 shared E. Xu· 2 shared J. Troncoso· 2 shared M. Albert· 2 shared S. Mori· 2 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBioengineering

K. Stouffer

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Amygdalar and ERC Rostral Atrophy and Tau Pathology Reconstruction in Preclinical Alzheimer's Disease

K. Stouffer, C. Chen, S. Kulason, E. Xu, M. Witter, C. Ceritoglu, M. Albert, S. Mori, J. Troncoso, D. J. Tward, M. I. Miller

This study measures amygdala and ERC atrophy rates in preclinical Alzheimer's disease using MRI and reconstructs 3D tau pathology distributions, finding amygdala atrophy comparable to ERC and suggesting it as a potential biomarker.

bioRxiv · Jun 6, 2022 · PreprintBioengineering

Projective LDDMM: Mapping Molecular Digital Pathology with Tissue MRI

K. Stouffer, M. Witter, D. J. Tward, M. I. Miller

This paper introduces Projective LDDMM, a method mapping dense MRI atlases to sparse histological measurements, with applications in Alzheimer's biomarker development.

bioRxiv · Apr 22, 2022 · PreprintBioengineering

Projective LDDMM: Spatially Reconstructing a Story of Rostrally-Dominant Tau in Alzheimer's Disease

K. Stouffer, M. Witter, C. Chen, E. Xu, M. Albert, S. Mori, J. Troncoso, D. J. Tward, M. Miller

The paper aligns 2D histology images of AD pathology with 3D MRI to reconstruct NFT density in the MTL, finding high NFT density in the rostral hippocampus and adjacent regions.

bioRxiv · Mar 16, 2022 · PreprintBioengineering

Hierarchical Computational Anatomy: Unifying the Molecular to Tissue Continuum via Measure Representations of the Brain

M. I. Miller, D. J. Tward, A. Trouve

This paper introduces a unified framework for brain mapping that integrates molecular and tissue scales using geometric measure representations, applied to Alzheimer's disease.

bioRxiv · Apr 19, 2021 · PreprintNeuroscience

CloudReg: Automatic Terabyte-Scale Cross-Modal Brain Volume Registration

V. Chandrashekhar, D. J. Tward, D. G. Crowley, A. K. Crow, M. A. Wright, B. Y. Hsueh, F. Gore, T. A. Machado, A. Branch, J. S. Rosenblum, K. Deisseroth, J. T. Vogelstein

CloudReg is a cloud-based pipeline that automatically registers large-scale multi-modal brain imaging data to atlases with high accuracy.

bioRxiv · Jan 26, 2021Bioengineering