K. Deisseroth

BrainLine: An Open Pipeline for Connectivity Analysis of Heterogeneous Whole-Brain Fluorescence Volumes

BrainLine processes whole-brain fluorescence images through registration, segmentation, and analysis using a feedback-based training approach.

In situ genetically targeted chemical assembly of polymers on living neuronal membranes

The paper develops a method to genetically target polymer assembly on neuronal membranes to modify electrical properties with improved efficiency and biocompatibility.

Genetically-encoded photosensitizers enable light-controlled polymerization on living neuronal membranes

This paper introduces a method to control polymerization on living neuronal membranes using light-activated photosensitizers, enabling non-invasive modification of neural circuits.

Structural basis for ion selectivity in potassium-selective channelrhodopsins

The paper determines the cryo-EM structures of two K+-selective channelrhodopsins, revealing a unique mechanism for K+ selectivity distinct from canonical K+ channels.

Topological supramolecular network enabled highly conductive and stretchable organic bioelectronics

This paper introduces a topological supramolecular network strategy to create highly conductive and stretchable organic bioelectronics with unprecedented performance in physiological environments.

Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine

The paper presents the cryo-EM structure of ChRmine, revealing unique architectural features and provides insights into its conduction mechanism and potential for optogenetic applications.

CloudReg: Automatic Terabyte-Scale Cross-Modal Brain Volume Registration

CloudReg is a cloud-based pipeline that automatically registers large-scale multi-modal brain imaging data to atlases with high accuracy.