Author

D. K. O'Flaherty

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3

Frequent Co-Authors

J. W. Szostak· 3 shared L. Zhou· 3 shared C. Giurgiu· 2 shared T. H. Wright· 2 shared A. Radakovic· 1 shared K. H. Ho· 1 shared S. C. Kim· 1 shared S. Kim· 1 shared

Activity by Year

2019-2019 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersBiochemistry

J. W. Szostak

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3 papers

Recent·Most cited

A model for the emergence of RNA from a prebiotically plausible mixture of ribonucleotides, arabinonucleotides and 2’-deoxynucleotides

S. Kim, L. Zhou, W. Zhang, D. K. O'Flaherty, V. Rondo-Brovetto, J. W. Szostak

This study investigates how RNA could emerge from prebiotic mixtures of ribonucleotides, arabinonucleotides, and 2'-deoxyribonucleotides through nonenzymatic template-directed synthesis.

bioRxiv · Oct 22, 2019Biochemistry

Non-enzymatic primer extension with strand displacement

L. Zhou, S. C. Kim, K. H. Ho, D. K. O'Flaherty, C. Giurgiu, T. H. Wright, J. W. Szostak

This study demonstrates non-enzymatic RNA primer extension through strand displacement using short RNA oligonucleotides, suggesting a prebiotic mechanism for RNA replication.

bioRxiv · Sep 16, 2019Biochemistry

Prebiotically Plausible ‘Patching’ of RNA Backbone Cleavage Through a 3′-5′ Pyrophosphate Linkage

T. H. Wright, C. Giurgiu, A. Radakovic, D. K. O'Flaherty, L. Zhou, J. W. Szostak

This study demonstrates that 3′-phosphate terminated RNA strands can participate in template-directed copying reactions to form stable pyrophosphate linkages, offering a non-enzymatic pathway for RNA strand recovery.

bioRxiv · Aug 10, 2019Biochemistry