D. Kazyken

Unexpected roles for AMPK in the suppression of autophagy and the reactivation of mTORC1 signaling during prolonged amino acid deprivation

This study shows that AMPK suppresses autophagy and supports mTORC1 signaling during prolonged amino acid deprivation, contradicting established views.

Alkaline intracellular pH activates AMPK-mTORC2 signaling to promote cell survival during growth factor limitation

The innate immune kinase TBK1 directly increases mTORC2 activity and downstream signaling to Akt

The innate immune kinase TBK1 directly activates mTORC2 to increase Akt phosphorylation in response to growth factors and poly(I:C).