HIF-dependent expression of creatine kinase brain isoform (CKB) promotes breast cancer metastasis, whereas cyclocreatine therapy impairs invasion and improves the efficacy of conventional chemotherapies
R. I. Krutilina, H. C. Playa, D. L. Brooks, L. P. Schwab, D. N. Parke, D. Oluwalana, D. R. Layman, M. Fan, D. L. Johnson, J. Yue, H. Smallwood, T. N. Seagroves
This study identifies CKB as a HIF-1 downstream gene promoting breast cancer metastasis and shows cyclocreatine therapy reduces invasion and enhances chemotherapy efficacy.
bioRxiv · Sep 9, 2021Cancer Biology