J. Yue

Covalent DNA-Encoded Library Workflow Drives Discovery of SARS-CoV-2 Non-structural Proteins Inhibitors

This study uses covalent DNA-encoded libraries to discover inhibitors targeting SARS-CoV-2 proteases 3CLpro and PLpro, identifying novel compounds with potent activity and unique binding modes.

GABRD promotes the progression of breast cancer through CDK1-dependent cell cycle regulation

This study shows GABRD promotes breast cancer progression by regulating the cell cycle through CDK1 interaction.

Multi-omics Comparison among Populations of Three Plant Sources of Amomi Fructus

This study compares multi-omics data across three plant sources of Amomi Fructus to identify genetic and transcriptomic differences, including gene flow and metabolic variation between populations.

Multi-omics analyses of single cell-derived colorectal cancer organoids reveal intratumor heterogeneity and immune response diversity

Identification of a small chemical as a lysosomal calcium mobilizer and characterization of its ability to inhibit autophagy and viral infection

The paper identifies G42 as a lysosomal calcium mobilizer that inhibits autophagy and viral infections by alkalizing lysosomal pH and blocking autophagosome-lysosome fusion.

CRISPR-induced exon skipping of β-catenin reveals tumorigenic mutants driving distinct subtypes of liver cancer

This study shows CRISPR/Cas9 can induce exon skipping in β-catenin, creating gain-of-function mutations that drive distinct liver cancer subtypes in mice and are found in human HCC patients.

Global Mutational Sweep of SARS-CoV-2: from Chaos to Order

The paper analyzes SARS-CoV-2 genome sequences to show mutation sweeps driven by emerging variants, which may prolong the pandemic and challenge control efforts.

HIF-dependent expression of creatine kinase brain isoform (CKB) promotes breast cancer metastasis, whereas cyclocreatine therapy impairs invasion and improves the efficacy of conventional chemotherapies

This study identifies CKB as a HIF-1 downstream gene promoting breast cancer metastasis and shows cyclocreatine therapy reduces invasion and enhances chemotherapy efficacy.

Reassortment Network of Influenza A Virus

This study analyzes the reassortment network of Influenza A Virus using genome-wide data to identify reassortment events and their evolutionary implications.

Gastric cancer derived exosomes induce peritoneal mesothelial cell EMT through TGF-β1/Smads pathway to promote peritoneal metastasis

This study shows GC-derived exosomes induce EMT in peritoneal mesothelial cells via TGF-β1/Smads pathway, enhancing GC cell migration and adhesion.

Polycomb repressive complex 2 coordinates with Sin3 histone deacetylase complex to epigenetically reprogram genome-wide expression of effectors and regulate pathogenicity in Magnaporthe oryzae

The paper shows that Polycomb repressive complex 2 and Sin3 histone deacetylase complex work together to epigenetically control effector gene expression in Magnaporthe oryzae, regulating its pathogenicity.

Development of next-generation sequencing-based sterility test

This study develops a next-generation sequencing-based sterility test (NGSST) that reduces detection time to 48 hours and improves accuracy for biological products.

Diversity and composition of gut microbiome of cervical cancer patients by 16S rRNA and whole-metagenome sequencing

This study compares 16S rRNA and whole-metagenome sequencing in cervical cancer patients, finding congruence in diversity metrics but discrepancies in genus-level abundances.

Dynamic evolution of cervical cancer mutations during chemoradiation using novel sampling approach

This study uses whole exome sequencing to track cervical cancer mutations during chemoradiation, finding that CDK4/CDK6/cyclin D1-related mutations persist or increase, suggesting radiation resistance.

Different subtypes of influenza A viruses target different human proteins and pathways leading to different pathogenic phenotypes

This study identifies subtype-specific influenza A virus-host protein interactions that correlate with different pathogenic outcomes.

Optical Sectioning of Live Mammal with Near-Infrared Light Sheet

This paper develops near-infrared light sheet microscopy to image live mammals, revealing tumor dynamics and PD-L1 receptor distribution at the single-cell level.