Spatially resolved DNP-assisted NMR illuminates the conformational ensemble of α-synuclein in intact viable cells.
J. Kragelj, R. Ghosh, Y. Xiao, R. Dumarieh, D. Lagasca, S. Krishna, K. K. Frederick
This study uses DNP-assisted NMR to show that α-synuclein adopts helical-rich conformations near the cell periphery in intact cells.
bioRxiv · Oct 24, 2023Biophysics