Author

J. Kragelj

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 3 Organism:mouse· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

K. K. Frederick· 4 shared Y. Xiao· 4 shared R. Dumarieh· 2 shared R. Ghosh· 2 shared D. Lagasca· 1 shared F. Mentink-Vigier· 1 shared S. Krishna· 1 shared W. N. Costello· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 20 mutual co-author links

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4 shared papersBiophysics

K. K. Frederick

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4 papers

Recent·Most cited

Spatially resolved DNP-assisted NMR illuminates the conformational ensemble of α-synuclein in intact viable cells.

J. Kragelj, R. Ghosh, Y. Xiao, R. Dumarieh, D. Lagasca, S. Krishna, K. K. Frederick

This study uses DNP-assisted NMR to show that α-synuclein adopts helical-rich conformations near the cell periphery in intact cells.

bioRxiv · Oct 24, 2023Biophysics

DNP-assisted solid-state NMR enables detection of proteins at nanomolar concentrations in fully protonated cellular environments

W. N. Costello, Y. Xiao, F. Mentink-Vigier, J. Kragelj, K. K. Frederick

This paper demonstrates that DNP-assisted solid-state NMR can detect proteins at nanomolar concentrations in fully protonated cellular environments using isotopically enriched yeast prion protein.

bioRxiv · Feb 20, 2023Biophysics

The conformational ensemble of an intrinsically disordered protein explains peak shapes under DNP conditions

J. Kragelj, R. Dumarieh, Y. Xiao, K. K. Frederick

The paper predicts and interprets peak shapes for intrinsically disordered proteins under DNP conditions using dihedral angle populations, demonstrated with α-synuclein.

bioRxiv · Oct 22, 2022Biophysics

In-Cell Sensitivity-Enhanced NMR of Intact Living Mammalian Cells

R. Ghosh, Y. Xiao, J. Kragelj, K. K. Frederick

This study establishes conditions for dynamic nuclear polarization (DNP) assisted MAS NMR to detect proteins in viable mammalian cells at micromolar concentrations.

bioRxiv · May 28, 2021Biophysics