NTR 2.0: a rationally-engineered prodrug converting enzyme with substantially enhanced efficacy for targeted cell ablation
A. v. Sharrock, T. S. Mulligan, K. R. Hall, E. M. Williams, D. T. White, L. Zhang, F. Matthews, S. Nimmagadda, S. Washington, K. Le, D. Meir-Levi, O. L. Cox, M. T. Saxena, A. Calof, M. E. Lopez-Burks, , J. S. Mumm
This paper describes the development of NTR 2.0, a modified nitroreductase with significantly improved efficacy for targeted cell ablation using metronidazole.
bioRxiv · May 22, 2020Cell Biology