Author

A. v. Sharrock

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Assay:metagenomics· 1 Research Focus:perturbation response prediction· 1 Research Focus:protein folding & dynamics· 1 Organism:zebrafish· 1

Frequent Co-Authors

D. F. Ackerley· 2 shared E. M. Williams· 2 shared F. Matthews· 2 shared J. S. Mumm· 2 shared M. T. Saxena· 2 shared T. S. Mulligan· 2 shared A. Calof· 1 shared A. D. Lander· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBiochemistry

D. F. Ackerley

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Author profile →

2 papers

Recent·Most cited

A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening

M. H. Rich, A. V. Sharrock, T. S. Mulligan, F. Matthews, A. S. Brown, H. R. Lee-Harwood, E. M. Williams, J. N. Copp, R. F. Little, J. J. Francis, C. N. Horvat, L. J. Stevenson, J. G. Owen, M. T. Saxena, J. S. Mumm, D. F. Ackerley

This paper introduces a metagenomic library cloning strategy using partial digestion with Fatl to enhance gene expression, enabling the discovery of nitroreductases with novel functions.

Cell Chemical Biology · Dec 1, 2023Peer-reviewedBiochemistry

NTR 2.0: a rationally-engineered prodrug converting enzyme with substantially enhanced efficacy for targeted cell ablation

A. v. Sharrock, T. S. Mulligan, K. R. Hall, E. M. Williams, D. T. White, L. Zhang, F. Matthews, S. Nimmagadda, S. Washington, K. Le, D. Meir-Levi, O. L. Cox, M. T. Saxena, A. Calof, M. E. Lopez-Burks, , J. S. Mumm

This paper describes the development of NTR 2.0, a modified nitroreductase with significantly improved efficacy for targeted cell ablation using metronidazole.

bioRxiv · May 22, 2020Cell Biology