Author

D. Mitrovic

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:protein folding & dynamics· 3 Approach:deep learning· 2 Assay:protein structure· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1 Assay:proteomics· 1

Frequent Co-Authors

L. Delemotte· 4 shared C. Alleva· 2 shared D. Drew· 2 shared M. Bonaccorsi· 2 shared A. Marciniak· 1 shared C. Macdonald· 1 shared D. B. Silva· 1 shared D. Trinidad· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersBiophysics

L. Delemotte

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4 papers

Recent·Most cited

Coevolution-driven method for efficiently simulating conformational changes in proteins reveals molecular details of ligand effects in the beta2AR receptor

D. Mitrovic, Y. Chen, A. Marciniak, L. Delemotte

This paper introduces a coevolution-driven method to simulate protein conformational changes, revealing ligand effects on the beta2AR receptor's activation and signaling pathways.

bioRxiv · Jul 20, 2023Biophysics

The full spectrum of OCT1 (SLC22A1) mutations bridges transporter biophysics to drug pharmacogenomics

S. W. Yee, C. Macdonald, D. Mitrovic, X. Zhou, M. Koleske, J. Yang, D. B. Silva, P. R. Grimes, D. Trinidad, S. S. More, L. Kachuri, J. S. Witte, L. Delemotte, K. M. Giacomini, W. Coyote-Maestas

This study examines OCT1 mutations to understand their impact on drug response and identifies population-specific allele frequencies linked to LDL cholesterol levels.

bioRxiv · Jun 6, 2023 · PreprintBiophysics

Reconstructing the transport cycle in the sugar porter superfamily using coevolution-powered machine learning

D. Mitrovic, S. E. McComas, C. Alleva, M. Bonaccorsi, D. Drew, L. Delemotte

The paper uses coevolution analysis and comparative modeling to predict the transport cycle states of the sugar porter superfamily and defines molecular determinants of the cycle.

bioRxiv · Sep 24, 2022Biophysics

Determinants of sugar-induced influx in the mammalian fructose transporter GLUT5

S. McComas, T. Reichenbach, D. Mitrovic, C. Alleva, M. Bonaccorsi, L. Delemotte, D. Drew

This study shows GLUT5 transitions through an occluded state similar to PfHT1, with fructose binding lowering energetic barriers and enabling fast sugar flux through allosteric coupling.

bioRxiv · Jun 17, 2022Biophysics