Author

W. Coyote-Maestas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:protein folding & dynamics· 4 Assay:proteomics· 4 Approach:deep learning· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. Schmidt· 4 shared D. Nedrud· 3 shared Y. He· 3 shared C. L. Myers· 2 shared A. Suma· 1 shared C. Macdonald· 1 shared D. B. Silva· 1 shared D. M. Fowler· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersBiochemistry

D. Schmidt

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The full spectrum of OCT1 (SLC22A1) mutations bridges transporter biophysics to drug pharmacogenomics

S. W. Yee, C. Macdonald, D. Mitrovic, X. Zhou, M. Koleske, J. Yang, D. B. Silva, P. R. Grimes, D. Trinidad, S. S. More, L. Kachuri, J. S. Witte, L. Delemotte, K. M. Giacomini, W. Coyote-Maestas

This study examines OCT1 mutations to understand their impact on drug response and identifies population-specific allele frequencies linked to LDL cholesterol levels.

bioRxiv · Jun 6, 2023 · PreprintBiophysics

Determinants of trafficking, conduction, and disease within a K+ channel revealed through multiparametric deep mutational scanning

W. Coyote-Maestas, D. Nedrud, Y. He, D. Schmidt

The paper uses deep mutational scanning to analyze how mutations affect Kir2.1 channel function, trafficking, and disease, revealing structural and functional determinants of pathogenicity.

bioRxiv · Jan 6, 2022Biochemistry

The biophysical basis of protein domain compatibility

W. Coyote-Maestas, D. Nedrud, A. Suma, Y. He, K. A. Matreyek, D. M. Fowler, V. Carnevale, C. L. Myers, D. Schmidt

The paper uses high-throughput assays and machine learning to model biophysical interactions governing protein domain compatibility in fusion proteins.

bioRxiv · Dec 9, 2020 · PreprintBiophysics

A survey of pairwise epistasis supports an outside-in hierarchy of clade-specifying and function-defining residues in PSD95 PDZ3

D. Nedrud, W. Coyote-Maestas, D. Schmidt

The paper uses deep mutational scanning to analyze epistasis in the PSD95 PDZ3 domain, revealing an outside-in hierarchy of clade-specifying and function-defining residues.

bioRxiv · Jun 26, 2020 · PreprintBiochemistry

Domain Insertion Permissibility is a Measure of Engineerable Allostery in Ion Channels

W. Coyote-Maestas, Y. He, C. L. Myers, D. Schmidt

The paper introduces domain insertion permissibility as a metric to identify engineerable allosteric sites in ion channels, showing light sensitivity when inserted into allosteric sites.

bioRxiv · Aug 9, 2018Biochemistry