IL-1α secreted by subcapsular sinus macrophages promotes melanoma metastasis in the sentinel lymph node by upregulating STAT3 signaling in the tumor.
T. Virgilio, J. Bordini, G. Sartori, I. Latino, D. Molina-Romero, C. Leoni, M. Akhmedov, A. Rinaldi, A. J. Arribas, D. Morone, S. M. S. Jafari, M. Bersudsky, A. Ottolenghi, I. Kwee, A. M. Chiaravalli, , S. F. Gonzalez
This study shows that IL-1α from subcapsular sinus macrophages promotes melanoma metastasis by enhancing STAT3 signaling in tumor cells, and blocking this pathway reduces metastasis.
bioRxiv · Oct 11, 2021 · PreprintImmunology