Author

D. N. Boone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

A. V. LEE· 2 shared A. Nagle· 1 shared A. Warburton· 1 shared B. M. Jacobsen· 1 shared J. A. Scott· 1 shared J. Kehm· 1 shared J. M. Atkinson· 1 shared K. Burlbaugh· 1 shared

Activity by Year

2018-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

A. V. LEE

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2 papers

Recent·Most cited

A negative feedback loop between Insulin-like Growth Factor signaling and the lncRNA SNHG7 tightly regulates transcript levels and proliferation

D. N. Boone, A. Warburton, S. Som, A. V. LEE

The paper shows IGF1 signaling down-regulates SNHG7, a lncRNA that promotes breast cancer cell proliferation and modulates IGF1 signaling through a feedback mechanism, with SNHG7 overexpression linked to poor patient outcomes.

bioRxiv · Jul 22, 2019Cancer Biology

Loss of E-cadherin enhances IGF1-IGF1R pathway activation and sensitizes breast cancers to anti-IGF1R inhibitors

A. Nagle, K. M. Levine, N. Tasdemir, J. A. Scott, K. Burlbaugh, J. Kehm, T. A. Katz, D. N. Boone, B. M. Jacobsen, J. M. Atkinson, S. Oesterreich, A. V. Lee

This study shows that loss of E-cadherin increases IGF1R pathway activation and makes breast cancers more responsive to anti-IGF1R therapies.

Clinical Cancer Research · Oct 15, 2018Peer-reviewedCancer Biology