Author

N. Tasdemir

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 6

Signature Assays, Organisms & Methods

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Organism:human· 6 Assay:bulk RNA-seq· 5 Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

S. Oesterreich· 6 shared K. M. Levine· 5 shared A. V. LEE· 4 shared J. M. Atkinson· 3 shared K. Ding· 3 shared B. M. Jacobsen· 2 shared E. A. Bossart· 2 shared N. E. Davidson· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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6 shared papersCancer Biology

S. Oesterreich

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6 papers

Recent·Most cited

Estrogen regulation and functional role of FGFR4 in estrogen receptor positive breast cancer

K. Ding, L. Chen, K. M. Levine, M. J. Sikora, N. Tasdemir, D. Dabbs, R. Jankowitz, R. S. Hazan, O. S. Shah, J. M. Xavier, A. V. LEE, S. Oesterreich

This study investigates FGFR4's role in endocrine resistance in ER+ breast cancer and finds it does not generally mediate resistance, though HER2-like subtypes may respond to FGFR4 inhibition.

bioRxiv · Mar 18, 2024 · PreprintCancer Biology

WCRC-25: A novel luminal Invasive Lobular Carcinoma cell line model

A. Elangovan, E. A. Bossart, A. Basudan, N. Tasdemir, O. S. Shah, K. Ding, S. C. Purdy, C. Meier, T. Heim, C. Neumann, S. Attaran, L. Brown, J. Hooda, L. Miller, K. Kota, , S. Oesterreich

The paper introduces a new invasive lobular carcinoma cell line, WCRC-25, and demonstrates its molecular features and therapeutic response to PI3K/AKT inhibition.

bioRxiv · Sep 15, 2023 · PreprintCancer Biology

Hotspot ESR1 mutations are multimodal and contextual drivers of breast cancer metastasis

Z. Li, Y. Wu, M. E. Yates, N. Tasdemir, A. Bahreini, J. Chen, K. M. Levine, N. M. Priedigkeit, S. Ali, L. Buluwela, S. Arnesen, J. Gertz, J. K. Richer, B. Troness, D. El-Ashry, , S. Oesterreich

This study identifies ESR1 mutations as drivers of breast cancer metastasis by altering cell adhesion and migration through genomic and transcriptomic reprogramming.

bioRxiv · Feb 10, 2021 · PreprintCancer Biology

Proteomic and Transcriptomic Profiling Identifies Mediators of Anchorage-Independent Growth and Roles of Inhibitor of Differentiation Proteins in Invasive Lobular Breast Cancer

N. Tasdemir, K. Ding, K. M. Levine, T. Du, E. A. Bossart, A. V. Lee, N. E. Davidson, S. Oesterreich

The paper identifies ID1 and ID3 as novel drivers of anchorage-independent growth in invasive lobular breast cancer through proteomic and transcriptomic profiling.

bioRxiv · Feb 7, 2019 · PreprintCancer Biology

Loss of E-cadherin enhances IGF1-IGF1R pathway activation and sensitizes breast cancers to anti-IGF1R inhibitors

A. Nagle, K. M. Levine, N. Tasdemir, J. A. Scott, K. Burlbaugh, J. Kehm, T. A. Katz, D. N. Boone, B. M. Jacobsen, J. M. Atkinson, S. Oesterreich, A. V. Lee

This study shows that loss of E-cadherin increases IGF1R pathway activation and makes breast cancers more responsive to anti-IGF1R therapies.

Clinical Cancer Research · Oct 15, 2018Peer-reviewedCancer Biology

Comprehensive 2D and 3D phenotypic characterization of human invasive lobular carcinoma cell lines

N. Tasdemir, E. Bossart, Z. Li, Z. Li, K. M. Levine, B. M. Jacobsen, G. C. Tseng, N. E. Davidson, S. Oesterreich

This paper characterizes the 2D and 3D phenotypes of four human invasive lobular carcinoma cell lines, revealing unique features compared to invasive ductal carcinoma cell lines.

bioRxiv · Jun 7, 2018Cancer Biology