Allosteric substrate activation of SAMHD1 shapes deoxynucleotide triphosphate imbalances by interconnecting the depletion and biosynthesis of different dNTPs
C. McCown, C. H. Yu, D. N. Ivanov
This study reveals how SAMHD1's allosteric activation regulates dNTP levels by linking depletion and biosynthesis, impacting HIV-1 replication and dNTP homeostasis.
bioRxiv · Nov 14, 2023 · PreprintBiochemistry