The spindle assembly checkpoint functions during early development in non-chordate embryos.
J. Chenevert, M. Roca, L. Besnardeau, A. Ruggiero, D. Nabi, A. McDougall, R. R. Copley, E. Christians, S. Castagnetti
The paper evaluates SAC activation in early embryos of diverse metazoan species, finding two classes of embryos with or without SAC proficiency, and suggests SAC activity is default in metazoans, silenced in chordates.
bioRxiv · Mar 19, 2019Cell Biology