USP1 deubiquitinates protein kinase Akt to inhibit PI3K-Akt-FoxO signaling
D. Goldbraikh, D. Neufeld, Y. Mutlak-Eid, I. Lasry, A. Parnis, S. Cohen
The paper identifies USP1 as a deubiquitinase that inhibits PI3K-Akt-FoxO signaling by removing K63-linked ubiquitin from Akt, contributing to insulin resistance and malignancies.
bioRxiv · May 30, 2019 · PreprintCell Biology