S. Cohen

TDP-43 pathology links innate and adaptive immunity in amyotrophic lateral sclerosis

This study shows TDP-43 pathology activates immune cells in ALS, linking it to immune dysfunction and suggesting immune monitoring as a diagnostic tool.

Secondary metabolite profiling of Pseudomonas aeruginosa isolates reveals rare genomic traits

This study uses secondary metabolite profiling and whole-genome sequencing to identify rare genomic traits in Pseudomonas aeruginosa isolates that affect quorum sensing and metabolite biosynthesis.

Contact-FP: a dimerization-dependent fluorescent protein toolkit for visualizing membrane contact site dynamics

The paper introduces Contact-FP, a toolkit of dimerization-dependent fluorescent proteins to visualize membrane contact site dynamics between various organelles in live cells.

Distant lymph nodes compensate for resected tumor-draining lymph nodes during cancer immunotherapy

The paper shows that removing tumor-draining lymph nodes does not impair immune checkpoint blockade response, as distant lymph nodes compensate for the loss.

PRDM6 promotes medulloblastoma by repressing chromatin accessibility and altering gene expression

This study shows PRDM6 represses chromatin accessibility and alters gene expression in neuroepithelial stem cells, promoting medulloblastoma but not sufficient to drive Group 4 medulloblastoma alone.

Divergent Outcomes Of Myeloid Cell Infection By Gammaherpesvirus 68 Reveal Stepwise Regulation By Host And Viral Factors

This study shows that myeloid cells infected by gammaherpesvirus 68 exhibit divergent outcomes regulated by viral and host factors, with IL-4 converting restricted infection to productive replication.

APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size

This study shows APOE4 in astrocytes traffics to lipid droplets, altering their size and composition, which may contribute to Alzheimer's disease risk.

Proteasome gene expression is controlled by the coordinated functions of multiple transcription factors

The paper shows that multiple transcription factors coordinate proteasome gene expression in response to catabolic stimuli, identifying PAX4 and PALNRF-1 as key regulators.

Graph-pMHC: Graph Neural Network Approach to MHC Class II Peptide Presentation and Antibody Immunogenicity

The paper introduces graph-pMHC, a graph neural network for predicting MHC Class II peptide presentation and improves antibody immunogenicity risk prediction.

Insulin receptor turnover in fasting is dependent on beta-dystroglycan deglycosylation

The paper shows that insulin receptor turnover during fasting depends on beta-dystroglycan deglycosylation mediated by lysosomal enzymes and NAGLU-induced transcriptional activation.

Combined drought resistance strategies and the hydraulic limit in co-existing Mediterranean woody species

The paper examines drought resistance strategies in Mediterranean woody species, finding interspecific variation in hydraulic and osmotic traits that lead to narrow hydraulic safety margins and risk of mortality near their distribution's dry margin.

Perilipin 5 interacts with Fatp4 at membrane contact sites to promote lipid droplet-to-mitochondria fatty acid transport

This study identifies Plin5 and Fatp4 interaction at LD-mitochondria contacts, showing phosphorylation of Plin5 and Fatp4's role in fatty acid transport during starvation.

The AAA-ATPase Atad1 and its partners promote degradation of desmin intermediate filaments in muscle

This study identifies ATAD1 and its partners PLAA and UBXN4 as facilitators of desmin intermediate filament degradation in muscle, revealing their role in promoting ubiquitinated desmin release and calpain-1 cleavage.

Recapitulation of patient-specific 3D chromatin conformation using machine learning and validation of identified enhancer-gene targets

The paper develops a machine learning model to predict enhancer-gene connections from ATAC-seq and RNA-seq data, validated using multi-omics data and CRISPRi in cancer patients.

A novel and highly divergent Canine Distemper Virus lineage causing distemper in ferrets in Australia

This paper reports a novel, highly divergent Canine Distemper Virus lineage causing distemper in ferrets in Australia, with less than 93% similarity to other lineages and vaccine strains.

Chromosome-level genome assembly of a human fungal pathogen reveals synteny among geographically distinct species

This study presents chromosome-level genome assemblies of five Histoplasma strains, revealing synteny and gene expression patterns across geographically distinct isolates.

Adaptive current-flow models of ECT: Explaining individual static impedance, dynamic impedance, and brain current delivery

This paper develops adaptive current-flow models of electroconvulsive therapy (ECT) to explain individual variations in static and dynamic impedance and brain current delivery.

Role of Specialized mSWI/SNF Complexes in Prostate Cancer Lineage Plasticity

The paper investigates the role of mSWI/SNF complexes in NEPC lineage plasticity using patient data and cell models, finding deregulated subunits and SMARCA4 overexpression linked to aggressive disease.

Chromatin accessibility profiles of castration-resistant prostate cancers reveal novel subtypes and therapeutic vulnerabilities

This study identifies four subtypes of castration-resistant prostate cancer using ATAC-seq and RNA-seq data, revealing novel therapeutic targets and classification for 370 patients.

Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide

This study investigates the dynamics of Aβ42 oligomers during amyloid fibril formation, revealing that most oligomers dissociate into monomers rather than forming fibrils.

Critical role for cold shock protein YB-1 in cytokinesis

This study identifies YB-1's role in cytokinesis by showing its necessity for microtubule organization and phosphorylation-dependent function.

DNA damage induced during mitosis undergoes DNA repair synthesis

This study uses laser-induced DNA damage in mitotic cells to show DNA repair occurs, is affected by DNA-PKcs and ATM, and reveals 25% of damaged cells proceed to mitosis.

Mass spectrometry reveals the chemistry of formaldehyde cross-linking in structured proteins

This study uses mass spectrometry to show that formaldehyde cross-linking in proteins involves two carbon atoms, not one, and identifies new structural insights from cross-links in human cells.

Plasma-derived exosomal analysis and deconvolution enables prediction and tracking of melanoma checkpoint blockade response

This paper uses plasma-derived exosomal RNA to predict and track melanoma response to immune checkpoint inhibitors by analyzing tumor and immune signatures.

Discovery of small-molecule inhibitors targeting the ribosomal peptidyl transferase center (PTC) of M. tuberculosis

The paper identifies small-molecule inhibitors targeting the ribosomal peptidyl transferase center of M. tuberculosis using NMR and machine learning, showing improved potency over standard antibiotics.

USP1 deubiquitinates protein kinase Akt to inhibit PI3K-Akt-FoxO signaling

The paper identifies USP1 as a deubiquitinase that inhibits PI3K-Akt-FoxO signaling by removing K63-linked ubiquitin from Akt, contributing to insulin resistance and malignancies.

Novel signaling hub of insulin receptor, dystrophin glycoprotein complex and plakoglobin regulates muscle size

Histone deacetylase inhibitors reduce the number of herpes simplex virus-1 genomes initiating expression in individual cells.