Cancer BiologybioRxiv
Synthetic lethality in large-scale integrated metabolic and regulatory network models of human cells
N. Barrena, L. Valcarcel, D. Olaverri-Mendizabal…·F. J. Planes
The paper extends genetic Minimal Cut Sets (gMCS) to integrate metabolic and regulatory networks, identifying synthetic lethal gene pairs in human cancer cell lines.
DOI 10.1038/s41540-023-00296-3