Lineage transcription factors co-regulate subtype-specific genes providing a roadmap for systematic identification of small cell lung cancer vulnerabilities
K. Pozo, R. K. Kollipara, D. P. Kelenis, K. E. Rodarte, X. Zhang, J. D. Minna, J. E. Johnson
This study identifies lineage transcription factors and super-enhancer signatures in SCLC, revealing co-regulation of subtype-specific genes and highlighting ASCL1 as a key dependency.
bioRxiv · Aug 13, 2020 · PreprintCancer Biology