J. D. Minna

A Lung Cancer Mouse Model Database

The paper establishes a database of lung cancer mouse models to improve data comparison and translational relevance by aligning mouse mutations with human lung cancer mutations.

ASCL1-ERK1/2 Axis: ASCL1 restrains ERK1/2 via the dual specificity phosphatase DUSP6 to promote survival of a subset of neuroendocrine lung cancers

This study identifies the ASCL1-DUSP6-ERK1/2 axis as a mechanism promoting survival in neuroendocrine lung cancers, suggesting DUSP6 as a potential therapeutic target.

Lineage transcription factors co-regulate subtype-specific genes providing a roadmap for systematic identification of small cell lung cancer vulnerabilities

This study identifies lineage transcription factors and super-enhancer signatures in SCLC, revealing co-regulation of subtype-specific genes and highlighting ASCL1 as a key dependency.

Relationship Between Neuroendocrine and Immune Gene Expression in Small Cell Lung Cancer

This study examines the relationship between neuroendocrine and immune gene expression in SCLC, finding that variant SCLC tumors regain immune gene expression and exhibit higher tumor-immune interactions.

Lung cancer models reveal SARS-CoV-2-induced EMT contributes to COVID-19 pathophysiology

The paper investigates how SARS-CoV-2 infection induces epithelial-mesenchymal transition (EMT) in lung cancer models, leading to changes in gene expression and potential therapeutic targets.

SCLC_CellMiner: Integrated Genomics and Therapeutics Predictors of Small Cell Lung Cancer Cell Lines based on their genomic signatures

SCLC_CellMiner provides an integrated resource of 118 SCLC cell lines with omics data and drug sensitivity, identifying molecular subtypes and therapeutic targets.