Author

D. Paffenholz

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Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

A. E. Torda· 1 shared A. Sutinen· 1 shared G. T. T. Nguyen· 1 shared P. Kursula· 1 shared S. Ruskamo· 1 shared

Activity by Year

2022-2022 · peak 1/yr

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5 top collaborators · 10 mutual co-author links

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1 shared paperBiochemistry

A. E. Torda

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1 paper

Recent·Most cited

Conserved intramolecular networks in GDAP1 are closely connected to CMT-linked mutations and protein stability

A. Sutinen, D. Paffenholz, G. T. T. Nguyen, S. Ruskamo, A. E. Torda, P. Kursula

This study analyzes GDAP1 mutations linked to CMT, showing they affect protein stability and conserved intramolecular networks, potentially leading to mitochondrial dysfunction and neuronal degeneration.

bioRxiv · Sep 9, 2022Biochemistry