Dual acting small-Molecule inhibitors targeting Mycobacterial DNA replication
M. Singh, S. Ilic, B. Tam, Y. Ben-Ishay, D. Sherf, D. Pappo, B. Akabayov
This study develops dual-acting small-molecule inhibitors targeting Mtb DNA replication enzymes DnaG primase and DNA gyrase, with improved physicochemical properties and inhibitory effects.
bioRxiv · Jun 3, 2020Biochemistry