Author

B. Akabayov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 4 Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Assay:DNA methylation· 2 Approach:machine learning (classical)· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

S. Ilic· 5 shared B. Tam· 3 shared A. Afek· 2 shared A. Soffer· 2 shared D. Sherf· 2 shared D. Vilenchik· 2 shared M. Singh· 2 shared D. Lukatsky· 1 shared

Activity by Year

2018-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersBiochemistry

S. Ilic

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Cell-penetrating peptide conjugates of indole-3-acetic acid-based DNA primase/Gyrase inhibitors as potent antitubercular agents against planktonic and biofilm culture of Mycobacterium smegmatis

R. P. Dewangan, M. Singh, S. Ilic, B. Tam, B. Akabayov

bioRxiv · Dec 1, 2020Microbiology

Reconfiguring primase DNA-recognition sequences by using a data driven approach

A. Soffer, M. Ifrach, S. Ilic, A. Afek, H. Schussheim, D. Vilenchik, B. Akabayov

The paper uses a machine learning approach to analyze DNA-protein binding data and identifies DNA sequences recognized by T7 primase.

bioRxiv · Sep 29, 2020 · PreprintBiochemistry

Dual acting small-Molecule inhibitors targeting Mycobacterial DNA replication

M. Singh, S. Ilic, B. Tam, Y. Ben-Ishay, D. Sherf, D. Pappo, B. Akabayov

This study develops dual-acting small-molecule inhibitors targeting Mtb DNA replication enzymes DnaG primase and DNA gyrase, with improved physicochemical properties and inhibitory effects.

bioRxiv · Jun 3, 2020Biochemistry

SIRT6 is a DNA double-strand break sensor

D. Toiber, L. Onn, G. Cleitman, S. Ilic, M. Portillo, D. Stein, Z. Slobodnik, S. Kaluski, M. Einav, F. Erdel, I. Shirat, B. Akabayov

This study identifies SIRT6 as a DNA double-strand break sensor that activates downstream repair pathways and prevents genomic instability.

bioRxiv · Sep 11, 2019Biochemistry

Discovery of small-molecule inhibitors targeting the ribosomal peptidyl transferase center (PTC) of M. tuberculosis

B. Tam, D. Sherf, S. Cohen, S. A. Eisdorfer, M. Perez, A. Soffer, D. Vilenchik, S. R. Akabayov, G. Wagner, B. Akabayov

The paper identifies small-molecule inhibitors targeting the ribosomal peptidyl transferase center of M. tuberculosis using NMR and machine learning, showing improved potency over standard antibiotics.

bioRxiv · Aug 11, 2019Biochemistry

DNA sequence context controls the binding and processivity of T7 DNA primase

A. Afek, S. Ilic, J. Horton, D. Lukatsky, R. Gordan, B. Akabayov

This study uses HTPP to show that DNA sequence context affects T7 primase binding and primer length.

bioRxiv · Feb 17, 2018Biophysics