Author

D. Perez-Sala

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 6 Research Focus:cell signaling & trafficking· 5 Assay:proteomics· 4 Research Focus:protein folding & dynamics· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

M. A. Pajares· 6 shared A. E. Martinez· 3 shared P. Gonzalez-Jimenez· 3 shared V. Lalioti· 3 shared A. Monico· 2 shared A. Viedma-Poyatos· 2 shared E. Navarro-Carrasco· 2 shared S. Duarte· 2 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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6 shared papersCell Biology

M. A. Pajares

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Key role of vimentin in the organization of the primary cilium

V. Lalioti, D. Moneo-Corcuera, D. Perez-Sala

This study shows vimentin is present at the primary cilium and its depletion causes structural and morphological defects in cilia and centriolar organization.

bioRxiv · Jan 17, 2024 · PreprintCell Biology

Intracellular pH modulates vimentin remodeling in response to oxidants

A. E. Martinez, P. Martinez-Cenalmor, P. Gonzalez-Jimenez, C. Vidal-Verdu, M. A. Pajares, D. Perez-Sala

This study shows that intracellular pH modulates vimentin remodeling by oxidants through the thiol group at C328, affecting its susceptibility to oxidative and electrophilic stress.

bioRxiv · Dec 21, 2023 · PreprintCell Biology

Vimentin cysteine 328 modifications finely tune network organization and influence actin remodeling under oxidative and electrophilic stress

P. Gonzalez-Jimenez, S. Duarte, A. E. Martinez, E. Navarro-Carrasco, V. Lalioti, M. A. Pajares, D. Perez-Sala

bioRxiv · Mar 30, 2023 · PreprintCell Biology

Immunolocalization studies of vimentin and ACE2 on the surface of cells exposed to SARS-CoV-2 Spike proteins

V. Lalioti, S. Gonzalez-Sanz, I. Lois-Bermejo, P. Gonzalez-Jimenez, A. Viedma-Poyatos, A. Merino, M. A. Pajares, D. Perez-Sala

This study investigates the surface localization of vimentin and ACE2 in response to SARS-CoV-2 Spike proteins using immunofluorescence, revealing cell-type-specific colocalization patterns.

bioRxiv · May 4, 2021 · PreprintCell Biology

Elucidating vimentin interaction with zinc ions and its interplay with oxidative modifications through crosslinking assays and molecular dynamics simulations

A. Monico, J. Guzman-Caldentey, M. A. Pajares, S. Martin-Santamaria, D. Perez-Sala

This study investigates vimentin's interaction with zinc ions and oxidative modifications using crosslinking assays and molecular dynamics simulations, revealing zinc's role in stabilizing Cys328 and preventing alkylation.

bioRxiv · Feb 12, 2021 · PreprintBiochemistry

Dynamic posttranslational modifications of cytoskeletal proteins unveil hot spots under nitroxidative stress

E. Griesser, V. Vemula, A. Monico, D. Perez-Sala, M. Fedorova

The paper identifies PTMs in cytoskeletal proteins under nitroxidative stress and highlights 'hot spots' involved in redox sensing and cross-talk.

bioRxiv · Jan 24, 2021Cell Biology

Amoxicillin inactivation by thiol-catalyzed cyclization reduces protein haptenation and antibacterial potency

M. A. Pajares, T. Zimmerman, F. J. Sanchez-Gomez, A. Ariza, M. J. Torres, M. Blanca, F. J. Canada, M. I. Montanez, D. Perez-Sala

This study shows that thiol-catalyzed cyclization of amoxicillin reduces protein haptenation and antibacterial potency by converting it to diketopiperazine.

bioRxiv · May 26, 2019Pharmacology & Toxicology

Vimentin filaments interact with the mitotic cortex allowing normal cell division

S. Duarte, A. Viedma-Poyatos, E. Navarro-Carrasco, A. E. Martinez, M. A. Pajares, D. Perez-Sala

This study shows vimentin filaments redistribute to the mitotic cortex during cell division, with their tail domain essential for proper mitosis, and disruption leads to mitotic errors.

bioRxiv · Sep 30, 2018Cell Biology