Pharmacology & ToxicologybioRxiv
Amoxicillin inactivation by thiol-catalyzed cyclization reduces protein haptenation and antibacterial potency
M. A. Pajares, T. Zimmerman, F. J. Sanchez-Gomez…·D. Perez-Sala
This study shows that thiol-catalyzed cyclization of amoxicillin reduces protein haptenation and antibacterial potency by converting it to diketopiperazine.
DOI 10.3389/fphar.2020.00189