Author

D. R. Carpizo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Casabianca· 1 shared A. J. Blayney· 1 shared A. R. Blanden· 1 shared A. Roberts· 1 shared A. Sharma· 1 shared B. Ghaddar· 1 shared C. Demas· 1 shared C. Dudgeon· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. Casabianca

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Author profile →

2 papers

Recent·Most cited

Zinc shapes the folding landscape of p53 and establishes a new pathway for reactivating structurally diverse p53 mutants

A. R. Blanden, X. Yu, A. J. Blayney, C. Demas, J.-H. Ha, Y. Liu, T. Withers, D. R. Carpizo, S. N. Loh

This paper develops a thermodynamic model to analyze how p53 mutations affect zinc binding and stability, showing that synthetic zinc metallochaperones can reactivate diverse p53 mutants.

bioRxiv · Jul 23, 2020Biochemistry

A Novel Model of Pancreatic Cancer Dormancy Reveals Mechanistic Insights and a Dormancy Gene Signature with Human Relevance

C. Dudgeon, C. R. Harris, Y. Chen, B. Ghaddar, A. Sharma, M. M. Shah, A. Roberts, A. Casabianca, E. Collisson, V. Balachandran, P. Vertino, S. De, D. R. Carpizo

This study introduces a novel pancreatic cancer dormancy model, identifies a dormancy gene signature, and reveals mechanisms including chromatin remodeling and CCL5 as a novel marker.

bioRxiv · Apr 13, 2020 · PreprintCancer Biology